rosiglitazone - metformin

By SB Pharmco

What is this medication for?

This is a combination medication that contains 2 active ingredients: metformin and rosiglitazone. They are used together, along with diet and exercise, to lower blood glucose (sugar) levels for adults with type 2 diabetes. Antidiabetes medications such as metformin and rosiglitazone are used when diet, exercise, and weight reduction have not been found to lower blood glucose well enough on their own.

Rosiglitazone belongs to the class of medications called thiazolidinediones. Rosiglitazone works by reducing levels of blood glucose (sugar in the blood) by helping insulin work more effectively, making it easier for glucose to enter into the tissues of the body. Although rosiglitazone may start to lower blood glucose shortly after starting to take it, the maximum effects may not be reached until the medication has been taken for approximately 14 weeks.

Metformin belongs to the group of medications called biguanides. Metformin works by reducing the amount of glucose made by the liver and by making it easier for glucose to enter into the tissues of the body.

Your doctor may have suggested this medication for conditions other than those listed here. As well, some forms of this medication may not be used for all of the conditions discussed here. If you are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

Avandamet® is available as:

  • tablets
    • 2 mg rosiglitazone and 500 mg metformin
    • 4 mg rosiglitazone and 500 mg metformin
    • 2 mg rosiglitazone and 1,000 mg metformin
    • 4 mg rosiglitazone and 1,000 mg metformin
Some medications may have other generic brands available. Always ask your doctor or pharmacist about the safety of switching between brands of the same medication.

How should I use this medication?

The usual recommended starting dose of rosiglitazone – metformin will vary depending on what medications you are already taking. It should be taken twice daily with food. The dose may be increased or decreased until blood glucose is controlled.

The maximum daily dose is 8 mg of rosiglitazone and 2,000 mg of metformin (e.g., 2 tablets of the 2 mg per 500 mg strength twice daily).

It is very important to monitor blood glucose levels on a regular basis as directed by your doctor or diabetes specialist.

Use of this medication should be temporarily discontinued by people undergoing tests requiring intravenous injection of contrast materials that contain iodine.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Who should NOT take this medication?

Do not take this medication if you:

  • are allergic to rosiglitazone, metformin, or any ingredients of the medication
  • are undergoing tests requiring intravenous injection of contrast materials that contain iodine (in this case, this medication should be temporarily discontinued)
  • have acute or chronic metabolic acidosis, including diabetic ketoacidosis
  • have kidney disease or impaired kidney function
  • have severe heart failure (NYHA Class III or IV)
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The contents of this health site are for informational purposes only. Always seek the advice of your physician or other qualified healthcare provider regarding any questions you may have about a medical condition.

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