What side effects are possible with this medication?
A side effect is an unwanted response to a medication when it is taken in normal doses. It can be mild or severe, temporary or permanent, but does not occur in everyone. The following side effects have been reported by at least 1% of people taking this medication. If you develop any of these side effects (or any other side effects not listed here) or they change in intensity, speak to your doctor or pharmacist for advice on managing them and on the risks and benefits of the medication.
- abdominal pain
- back pain
- difficulty swallowing
- difficulty urinating
- dry mouth
- hair loss
- hearing or vision changes
- heart palpitations or flutters
- higher than normal blood pressure readings
- higher than normal blood sugar readings
- increased sweating
- menstrual problems
- racing heart rate
- rectal bleeding
- respiratory infection
- ringing in the ears
- runny nose
- skin infections (e.g., herpes simplex)
- skin rash (mild)
- sore throat
- stuffy nose
- swelling of the legs, ankles, or feet
- weight gain
to learn about serious side effects that can potentially occur with any medication. These examples are provided for information purposes only and are not meant to be exhaustive. Always consult your doctor for sound medical advice specific to your particular medication and treatment.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online or by phone at 1-800-332-1088.
Are there any other precautions or warnings for this medication?
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Allergic reactions: In rare cases, some people may develop an allergic reaction to this medication. Signs of an allergic reaction include a severe rash (that may include blisters and fever), a swollen face or throat, or difficulty breathing. If these occur, seek emergency medical care.
Anemia: Naproxen may cause or worsen anemia (loss of red blood cells). People more prone to anemia should get their blood tested regularly and check for signs of anemia (e.g., weakness and tiredness) while taking this medication.
Asthma: The use of NSAIDs or aspirin has worsened symptoms of asthma and the condition. You should be closely monitored by your doctor while taking this medication if you have asthma.
Blood pressure: This medication may cause increased blood pressure. You should be closely monitored by your doctor while taking this medication if you have high blood pressure.
Heart attack and stroke: People who take NSAIDs or COX-2 inhibitors have a higher risk of experiencing a heart attack or stroke. The risk for these side effects is higher with larger total daily doses and longer treatment periods. You may be at a higher risk and should be closely monitored by your doctors while taking this medication if you have heart disease or high blood pressure.
You should not be take this medication if you have had or are planning to have open heart (bypass) surgery. Seek immediate medical care if you have shortness of breath, chest pain, weakness in one part of one side of your body, or slurred speech.
Heart failure and fluid retention: People with heart failure, high blood pressure, or fluid retention may experience edema (swelling of the lower legs, ankles, and feet) or shortness of breath while taking NSAIDs (such as this medication) or COX-2 inhibitors. If you develop any of these symptoms while taking this medication, contact your doctor immediately.
Kidney disease: Long-term use of naproxen or other NSAIDs can cause kidney damage and thus is not recommended. In general, NSAIDs and COX-2 inhibitors are not recommended for people with severe kidney disease or limited kidney function.
Liver disease: Naproxen may affect your liver test results and worsen liver disease. You should be closely monitored by your doctors while taking this medication if you have liver disease. Stop taking naproxen and contact your doctor if your skin or eyes look yellow or if you are more tired or weak than usual.
Stomach ulcers: Naproxen may cause stomach problems such as ulcers or bleeding. Contact your doctor immediately if you experience stomach pain or vomit blood, or if you notice any black or tarry stools. The use of aspirin, corticosteroids (such as prednisone), or blood thinners at the same time as naproxen will increase the risk of stomach ulcers and bleeding and thus is not recommended.
Seniors have a higher risk of stomach ulcers when taking this medication. The risk of stomach ulcers also increases if you smoke, drink alcohol, have poor health and take higher total daily doses and longer treatment periods. However, stomach ulcers may happen at any time during treatment and without warning symptoms and may cause death.
Pregnancy: This medication should not be used during pregnancy. If you become pregnant while taking this medication, stop taking it immediately and call your doctor.
Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking this medication, talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of this medication have not been established for children less than 2 years of age.
Seniors: Seniors who take this medication should be closely monitored by their doctors. Seniors may be more likely to develop side effects and may require a lower dose.
What other drugs could interact with this medication?
There may be an interaction between naproxen sodium and any of the following:
- ACE inhibitors (e.g., enalapril, ramipril)
- aspirin and other salicylate medications
- beta-blockers (e.g., propranolol)
- corticosteroids (e.g., prednisone)
- other NSAIDs (e.g., ibuprofen, etodolac)
- selective serotonin reuptake inhibitor (SSRI) antidepressants
- thiazide diuretics (e.g., hydrochlorothiazide)
Extended-release formulations of naproxen sodium should not be taken with H2-blockers, sucralfate, and intensive antacid therapy.
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.