By GlaxoSmithKline

What is this medication for?

Amprenavir is no longer being manufactured for sale in the USA. This article is being kept available for reference purposes only. If you are using this medication, speak with your doctor or pharmacist for information about your treatment options.

Amprenavir belongs to the group of medications known as protease inhibitors. It is used in combination with other medications to treat people who have human immunodeficiency virus (HIV) infection. Amprenavir does not cure HIV or AIDS and does not prevent it from being spread to others. It does slow further growth or reproduction of HIV when used in combination with other medications, and it seems to slow down the destruction of the immune system. This may help to delay the development of problems that are related to AIDS or HIV disease.

Your doctor may have suggested this medication for conditions other than those listed here. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it. Do not stop taking this medication without consulting your doctor.

What form(s) does this medication come in?

Agenerase® is no longer being manufactured for sale in the USA.

Some medications may have other generic brands available. Always ask your doctor or pharmacist about the safety of switching between brands of the same medication.

How should I use this medication?

The dose of amprenavir capsules and oral solution are not equivalent. Do not substitute one form of amprenavir for the other. Take as directed by your doctor and pharmacist.

Capsules: For people not taking the antiviral medication ritonavir, the usual recommended dose of amprenavir for adults and adolescents over 12 years of age is 1,200 mg twice daily. If a person is also taking ritonavir, a lower dose may be used. The capsules should be swallowed whole. They should not be crushed or chewed.

For children aged 4 to 12 years, the dose of this medication is determined by your doctor based on weight and recommended doses.

Oral solution: The oral (by mouth) solution is recommended only for people who cannot swallow capsules and are not taking ritonavir oral solution.

The usual recommended dosage is based on age and body weight.

Amprenavir may be taken with or without food. It should not be taken with a high-fat meal, because this reduces the amount of medication that is absorbed by the body.

Finish all this medication, even if you have started to feel better

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is very important that this medication be used on a regular schedule as prescribed by the doctor. If you miss a dose of this medication, check with your healthcare professional. Do not take a double dose to make up for a missed one.

Who should NOT take this medication?

Amprenavir (capsules and oral solution) should not be used by anyone who:

  • is allergic to amprenavir or any ingredients of the medication
  • is taking any of the following:
    • benzodiazepines (e.g., midazolam, triazolam)
    • cisapride
    • ergot derivatives (e.g., dihydroergotamine, ergonovine, ergotamine, methylergonovine)
    • flecainide or propafenone (if using amprenavir with ritonavir)
    • pimozide

Amprenavir oral solution should not be used by anyone who:

  • has liver or kidney failure
  • is pregnant
  • is taking disulfiram or metronidazole
  • is younger than four years of age
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The contents of this health site are for informational purposes only. Always seek the advice of your physician or other qualified healthcare provider regarding any questions you may have about a medical condition.

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