agalsidase beta

By Genzyme

What is this medication for?

Agalsidase beta belongs to a group of medications known as enzyme replacement therapy. It is used to treat people with Fabry disease, which is a genetic disorder where the levels of alpha-galactosidase (an enzyme that breaks down fats) is low or absent. With Fabry disease, globotriaosylceramide (or GL-3 - a fat substance) is not removed from cells in the body and starts to accumulate in the walls of blood vessels and organs. By reducing GL-3 levels in the body, agalsidase beta slows the rate of progression of Fabry disease in the kidney, heart, and brain.

Your doctor may have suggested this medication for conditions other than those listed here. As well, some forms of this medication may not be used for all of the conditions discussed here. If you are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

What form(s) does this medication come in?

Fabrazyme® is available as:

  • vials
    • 5 mg
    • 35 mg
Some medications may have other generic brands available. Always ask your doctor or pharmacist about the safety of switching between brands of the same medication.

How should I use this medication?

The usual dose of agalsidase beta is 1 mg per kilogram of body weight given every 2 weeks as an infusion into a vein. You will also be given a medication such as acetaminophen, and possibly other medications, prior to receiving this medication in order to reduce some of the side effects associated with the infusion.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that this medication be given exactly as recommended by your doctor. If you miss an appointment to receive agalsidase beta, contact your doctor as soon as possible to reschedule your appointment. If you are receiving this medication at home and miss a dose, contact your doctor.

Vials of this medication are stored in the refrigerator. After prepared for an infusion, this medication should be used immediately, but can be stored for up to 24 hours at 36°F to 46°F (2°C to 8°C).

Who should NOT take this medication?

Do not take this medication if you are allergic to agalsidase beta or any ingredients of the medication.

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The contents of this health site are for informational purposes only. Always seek the advice of your physician or other qualified healthcare provider regarding any questions you may have about a medical condition.

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